Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.1
USERS' SCORE
Good
Based on 2 Reviews
8.5
Supplement Facts
Serving Size: 2 VegCaps
Amount Per Serving
%DV
Vitamin C (as Ascorbic Acid)
1,235 mg
1,372%
Quercetin
465 mg
*
Bromelain (Supplying 90 MCU)
50 mg
*
Top Medical Research Studies
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
9
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
9
We explored how vitamin C supplementation might affect rheumatoid arthritis (RA), an autoimmune disorder that causes chronic inflammation. Our research focused on whether vitamin C could help restore balance in gut microbiota, which previous findings indicated could worsen RA by breaking down vitamin C.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Using collagen-induced arthritis (CIA) mouse models, we conducted a series of tests, including biochemical and microbiological evaluations. The outcome was promising: vitamin C not only helped rebalance the gut microbiota but also reduced inflammation typical of RA, as seen in the notable decrease in pro-inflammatory cytokines like IL-6 and TNF-α.
In essence, the treatment with vitamin C showed significant benefits in alleviating RA symptoms in our study. These findings suggest that vitamin C could be a useful therapeutic option for managing rheumatoid arthritis effectively by targeting gut health.
Most Useful Reviews
9.5
Skin improvement confirmed
I ordered this complex to assist my body with allergic reactions. I took 2 capsules between meals, and after a month, I noticed a significant reduction in skin allergy symptoms. I highly recommend it!
8
Painless breathing experienced
Once, my children were frequently ill, struggling with persistent colds. After researching various remedies, I chose this dietary supplement, which arrived swiftly. They began taking it, albeit irregularly, but I have noticed that the issues with their maxillary sinuses have improved. I believe this is due to quercetin's effectiveness!
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 27 Researches
8.1
- All Researches
9
We explored how quercetin, a natural compound, may help alleviate symptoms of systemic lupus erythematosus (SLE), an autoimmune disorder. Our study observed that quercetin reduced kidney damage and swelling in the lymph nodes of lupus-affected mice. It appeared to lower the number of certain T cells that drive the disease and promoted cell death in aged immune cells. By influencing key pathways, quercetin showed potential as a therapy for SLE, offering hope in tackling this complex condition.
9
We explored the effects of quercetin, a flavonoid, on rheumatoid arthritis through a well-structured study involving collagen-induced arthritis models in rats. Quercetin was administered for four weeks, and various assessments were conducted to evaluate its impact on inflammation and joint health.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
Our findings revealed that quercetin significantly reduces joint inflammation and enhances metabolic function, mainly by inhibiting the JAK1/STAT3/HIF-1α signaling pathway. This suggests that quercetin could be a promising treatment option for mitigating symptoms of rheumatoid arthritis.
9
We explored how Sendeng-4, a traditional Mongolian medicine, can ease rheumatoid arthritis (RA). By using advanced methods to analyze its active components, we identified key phytochemicals and mapped their effects on biological pathways.
After testing on a rat model of RA, we observed that Sendeng-4 significantly reduces inflammation and arthritis symptoms, particularly through the PI3K-Akt signaling pathway. Overall, this study reveals Sendeng-4's potential benefits in treating RA and encourages further research into traditional remedies.
After testing on a rat model of RA, we observed that Sendeng-4 significantly reduces inflammation and arthritis symptoms, particularly through the PI3K-Akt signaling pathway. Overall, this study reveals Sendeng-4's potential benefits in treating RA and encourages further research into traditional remedies.
9
Quercetin liposomes aid diabetes therapy
We observed that a new form of quercetin, delivered in lipid nanoparticles, can help alleviate diabetes symptoms in rats. This improved bioavailable quercetin significantly reduced blood glucose levels and lowered pancreatic oxidative stress and inflammation.
It also enhanced autophagy while reducing endoplasmic reticulum stress markers. However, when combined with an autophagy inhibitor, the positive effects disappeared, indicating the importance of autophagy in quercetin’s benefits. Overall, this study highlights the potential of quercetin liposomes in managing type 1 diabetes.
It also enhanced autophagy while reducing endoplasmic reticulum stress markers. However, when combined with an autophagy inhibitor, the positive effects disappeared, indicating the importance of autophagy in quercetin’s benefits. Overall, this study highlights the potential of quercetin liposomes in managing type 1 diabetes.
9
We investigated how vitamin C, also known as ascorbic acid, might impact autoimmune disorders like rheumatoid arthritis. Through a study involving a mouse model of collagen-induced arthritis, we administered vitamin C or a placebo solution and observed the effects on the immune response and disease progression.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
Notably, the research showed that mice given vitamin C experienced a significant delay in the onset of arthritis and a reduction in disease severity. This suggests that vitamin C can play a critical role in managing autoimmune conditions by minimizing the production of autoantibodies, which are harmful antibodies that mistakenly attack the body's tissues.
Our findings revealed that vitamin C reduced the number of plasma cells and decreased antibody production in response to immunization. This indicates that vitamin C influences the immune system's response at a cellular level, helping to prevent the emergence of autoreactive plasma cells. We also discovered that the mechanism behind this effect involved inhibiting the Stat3 signaling pathway, leading to less activation of autoreactive immune components.
Ultimately, these results highlight the potential of vitamin C not just as a nutrient, but as a strategic tool in managing autoimmune disorders. By simply supplementing with vitamin C, there may be a way to intervene positively in the progression of diseases like rheumatoid arthritis.
User Reviews
USERS' SCORE
Good
Based on 2 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9.5
Skin improvement confirmed
I ordered this complex to assist my body with allergic reactions. I took 2 capsules between meals, and after a month, I noticed a significant reduction in skin allergy symptoms. I highly recommend it!
8
Painless breathing experienced
Once, my children were frequently ill, struggling with persistent colds. After researching various remedies, I chose this dietary supplement, which arrived swiftly. They began taking it, albeit irregularly, but I have noticed that the issues with their maxillary sinuses have improved. I believe this is due to quercetin's effectiveness!
Frequently Asked Questions
No FAQs are available for this product and symptom.
References
- Ren J, Liu Z, Qi X, Meng X, Guo L, et al. Active Ingredients and Potential Mechanism of Additive Sishen Decoction in Treating Rheumatoid Arthritis with Network Pharmacology and Molecular Dynamics Simulation and Experimental Verification. Drug Des Devel Ther. 2025;19:405. doi:10.2147/DDDT.S489323
- Yang J, Yang H, Wang F, Dai Y, Deng Y, et al. Bioinformatics identification based on causal association inference using multi-omics reveals the underlying mechanism of Gui-Zhi-Shao-Yao-Zhi-Mu decoction in modulating rheumatoid arthritis. Phytomedicine. 2025;136:156332. doi:10.1016/j.phymed.2024.156332
- Zhendong Y, Changjun C, Haocheng H, Qibin L, Dailing C, et al. Regulation of macrophage polarization and pyroptosis by 4-methylcatechol alleviates collagen-induced arthritis via Nrf2/HO-1 and NF-κB/NLRP3 signaling pathways. Int Immunopharmacol. 2025;146:113855. doi:10.1016/j.intimp.2024.113855
- Priya PS, Murugan R, Srileka R, Ramya Ranjan Nayak SP, Margesan T, et al. Synergistic defense: Quercetin and chondroitin sulfate combat bacterial trigger of rheumatoid arthritis, Proteus mirabilis through in-vitro and in-vivo mechanisms. Microb Pathog. 2024;197:107086. doi:10.1016/j.micpath.2024.107086
- Xiong F, Shen K, Long D, Zhou S, Ruan P, et al. Quercetin ameliorates lupus symptoms by promoting the apoptosis of senescent Tfh cells via the Bcl-2 pathway. Immun Ageing. 2024;21:69. doi:10.1186/s12979-024-00474-9
- Karnam S, Jindal AB, Paul AT. Quality by design-based optimization of teriflunomide and quercetin combinational topical transferosomes for the treatment of rheumatoid arthritis. Int J Pharm. 2024;666:124829. doi:10.1016/j.ijpharm.2024.124829
- Zhang F, Zhang Y, Zhou J, Cai Y, Li Z, et al. Metabolic effects of quercetin on inflammatory and autoimmune responses in rheumatoid arthritis are mediated through the inhibition of JAK1/STAT3/HIF-1α signaling. Mol Med. 2024;30:170. doi:10.1186/s10020-024-00929-1
- Wu Z, Hu J, Li Y, Yao X, Ouyang S, et al. Assessment of renal pathophysiological processes and protective effect of quercetin on contrast-induced acute kidney injury in type 1 diabetic mice using diffusion tensor imaging. Redox Rep. 2024;29:2398380. doi:10.1080/13510002.2024.2398380
- Guo X, Wu W, Ran Q, Wang L, Li Y, et al. Exploring the pharmacological mechanisms of the flower of Rhododendron molle in rheumatoid arthritis rats based on metabolomics integrated network pharmacology. J Ethnopharmacol. 2024;334:118524. doi:10.1016/j.jep.2024.118524
- Pei C, Yu J, Wang G, Jia YR, Shi X, et al. Exploring the mechanism of Sendeng-4 against rheumacid arthritis through integrated serum pharmacochemistry, transcriptomics, and network pharmacology. Biomed Chromatogr. 2024;38:e5893. doi:10.1002/bmc.5893
- Zhou F, Guo YX, Gao R, Ji XY, Tang YX, et al. Quercetin regulates dendritic cell activation by targeting STAT4 in the treatment of experimental autoimmune encephalomyelitis. Toxicol Appl Pharmacol. 2024;488:116980. doi:10.1016/j.taap.2024.116980
- Hossein A, Firouzeh G, Zeinab K, Gholamreza D. Quercetin prevents kidney against diabetes mellitus (type 1) in rats by inhibiting TGF-β/apelin gene expression. Mol Biol Rep. 2024;51:677. doi:10.1007/s11033-024-09617-z
- Hou Y, Chen C, Li Z, Wu J, Lyu S, et al. Protective effect of quercetin against macrophage-mediated hepatocyte injury via anti-inflammation, anti-apoptosis and inhibition of ferroptosis. Autoimmunity. 2024;57:2350202. doi:10.1080/08916934.2024.2350202
- Li X, Wang X, Qu X, Shi N, Li Q, et al. Microenvironmental Enzyme-Responsive Methotrexate Modified Quercetin Micelles for the Treatment of Rheumatoid Arthritis. Int J Nanomedicine. 2024;19:3259. doi:10.2147/IJN.S457004
- Chen J, Huang C, Li M. [ granule inhibits podocyte autophagy in systemic lupus erythematosus: a network pharmacology and clinical study]. Nan Fang Yi Ke Da Xue Xue Bao. 2024;44:465. doi:10.12122/j.issn.1673-4254.2024.03.07
- Khater SI, El-Emam MMA, Abdellatif H, Mostafa M, Khamis T, et al. Lipid nanoparticles of quercetin (QU-Lip) alleviated pancreatic microenvironment in diabetic male rats: The interplay between oxidative stress - unfolded protein response (UPR) - autophagy, and their regulatory miRNA. Life Sci. 2024;344:122546. doi:10.1016/j.lfs.2024.122546
- Zhang H, Zhang Y, Zhang Y, Wei H, Jin S, et al. Combination of inorganic nitrate and vitamin C prevents collagen-induced arthritis in rats by inhibiting pyroptosis. Food Funct. 2025;16:673. doi:10.1039/d4fo03096f
- Chen L, Mao Y, Chen G. Association between total vitamin C intake and hypothyroidism among Hashimoto thyroiditis: National Health and Nutrition Examination Survey, 2007-2012. Br J Nutr. 2024;132:1575. doi:10.1017/S0007114524001715
- Yin Y, Wu S. Ascorbic acid alleviates rheumatoid arthritis by inhibiting the production of autoantibodies. Cell Commun Signal. 2024;22:373. doi:10.1186/s12964-024-01756-x
- Isola S, Gammeri L, Furci F, Gangemi S, Pioggia G, et al. Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy. Int J Mol Sci. 2024;25. doi:10.3390/ijms25137284
- Ali A, Jori C, Kumar A, Vyawahare A, Kumar J, et al. A bioactive and biodegradable vitamin C stearate-based injectable hydrogel alleviates experimental inflammatory arthritis. Biomater Sci. 2024;12:3389. doi:10.1039/d4bm00243a
- Zhang Y, Zhen S, Xu H, Sun S, Wang Z, et al. Vitamin C alleviates rheumatoid arthritis by modulating gut microbiota balance. Biosci Trends. 2024;18:187. doi:10.5582/bst.2024.01037
- Zhang L, Li G, Lin B, He H, Zhou R, et al. Ascorbyl palmitate ameliorates inflammatory diseases by inhibition of NLRP3 inflammasome. Int Immunopharmacol. 2024;131:111915. doi:10.1016/j.intimp.2024.111915
- Santiworakul C, Saisorn W, Siripen N, Leelahavanichkul A, Rianthavorn P. Interleukin-8 and neutrophil extracellular traps in children with lupus nephritis and vitamin C deficiency. Pediatr Nephrol. 2024;39:1135. doi:10.1007/s00467-023-06189-1
- Mungan S, Guzel I, Demirdogen BC. Association between Expanded Disability Status Scale score and dietary antioxidant capacity in patients with multiple sclerosis. Braz J Med Biol Res. 2023;56:e12776. doi:10.1590/1414-431X2023e12776
- Farasati Far B, Behnoush AH, Ghondaghsaz E, Habibi MA, Khalaji A. The interplay between vitamin C and thyroid. Endocrinol Diabetes Metab. 2023;6:e432. doi:10.1002/edm2.432
- Ueki M, Sakamoto K, Nishioka N, Ohata H, Nobuta T, et al. Rheumatologic manifestations with elevated levels of IL-6, IL-17A, and IL-23 in a patient with scurvy. Mod Rheumatol Case Rep. 2023;7:302. doi:10.1093/mrcr/rxac059
